RAF Typhoon FGR4s have joined forces with France's air force in a joint strike targeting an subterranean weapons facility in Syria operated by the Daesh militant organization, as stated by the British defence ministry.
The site, identified by intelligence, was assessed as storing arms and explosives, the statement said, and was located in hills just north of the ancient city of Palmyra in Syria's central region.
"The RAF jets employed laser-guided Paveway IV weapons to target a number of entry passages down to the facility... early reports indicate the strike was effective," the MoD said.
There was no sign of any civilian casualties in the attack on Saturday evening and all the aircraft made a safe return, the ministry further stated.
The Typhoon fighters were backed up by a Voyager tanker plane.
IS - also known as Daesh - imposed militant control over parts of Syria and Iraq before its territorial defeat in 2019.
"This action shows the UK's leading role, and determination to operate in unison with allied nations, to eradicate any resurgence of Daesh and their dangerous and violent ideologies in the area," Britain's Defence Chief the minister said.
British military aircraft have conducted patrols over Syrian airspace to "prevent any attempted resurgence" of IS following its routing at the battle of Baghuz in the year 2019, the ministry said.
"I must thank all the members of British forces participating in this operation for their professionalism and their courage," Healey said. "They were part of numerous British troops on duty over the holidays. This operation, to eliminate militants who threaten our way of life, demonstrates how British military are ready to step up, continuously, protecting the UK at home and influential overseas."
Last December, the US military executed what it described as a "massive strike" against IS targets in Syria, following an attack resulted in the deaths of two US servicemembers and a local interpreter in the Palmyra area.
The U.N. says Islamic State still has roughly 5-7 thousand combatants in Syria and Iraq.